Publications

Current list of publications from the department of Hepatology

Papers

Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomedicine & Pharmacotherapy. 2019 Vol 111. doi.org/10.1016/j.biopha.2019.01.020

https://www.sciencedirect.com/science/article/pii/S0753332218372676

Letter to the editor: ‘Human based systems: Mechanistic NASH modelling just around the corner?’ Pharmacol Res. 2018 Nov;137:280-281. doi: 10.1016/j.phrs.2018.09.028

https://www.sciencedirect.com/science/article/pii/S1043661818313525?via%3Dihub

Nondestructive optical toxicity assays of 3D liver spheroids with optical coherance tomography. Adv Biosystems. 2018 Volume2, Issue3 doi.org/10.1002/adbi.201700212

https://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201700212

Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver. Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541

https://www.nature.com/articles/srep37541

Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):30-37. doi: 10.1111/bcpt.12631

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225883/

Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. Lipids Health Dis. 2016 Jul 2;15:114. doi: 10.1186/s12944-016-0283-7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930558/

Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model. Sci Rep. 2015 Dec 3;5:17455. doi: 10.1038/srep17455

https://www.ncbi.nlm.nih.gov/pubmed/26632255

Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events? Lipids Health Dis. 2015 Aug 10;14:86. doi: 10.1186/s12944-015-0069-3

https://www.ncbi.nlm.nih.gov/pubmed/26256740

(1)H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy. World J Hepatol. 2015 Jun 28;7(12):1701-7. doi: 10.4254/wjh.v7.i12.1701.

https://www.ncbi.nlm.nih.gov/pubmed/26140090

Toxicology of ZnO and TiO2 nanoparticles on hepatocytes: impact on metabolism and bioenergetics. Nanotoxicology. 2015 Feb;9(1):126-34. doi:10.3109/17435390.2014.895437.

https://www.ncbi.nlm.nih.gov/pubmed/24708275

Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro. Sci Rep. 2013;3:2735. doi: 10.1038/srep02735

https://www.ncbi.nlm.nih.gov/pubmed/24061220

Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis. Liver Int. 2012 Aug;32(7):1079-92. doi: 10.1111/j.1478-3231.2012.02775.x.

https://www.ncbi.nlm.nih.gov/pubmed/22429485

Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure. World J Gastroenterol. 2011 Mar 21;17(11):1457-61. doi: 10.3748/wjg.v17.i11.1457.

https://www.ncbi.nlm.nih.gov/pubmed/21472104

Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure. BMC Gastroenterol. 2010 Mar 30;10:34. doi: 10.1186/1471-230X-10-34.

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-34

Abstracts/Posters

Chlorpromazine disrupts structural integrity of hepatic cell membranes in human HepaRG cells and initiates a pro-inflammatory response (1.44 MB / PDF)

Towards understanding the mechanisms of chlorpromazine induced hepatic toxicity (526.29 KB / PDF)

Development of a 3D HepaRG based non-invasive optical imaging platform for pre-clinical hepatotoxicity screening (866.16 KB / PDF)

Using an impedance based assay in the investigation of drug induced liver injury comprising the gut/liver axis (2.27 MB / PDF)

Electronic-nose breath print distinguishes non-alcoholic fatty liver disease from healthy lean control: a pilot study (465.75 KB / PDF)

A study of breath metabolome in Non-Alcoholic Fatty Liver Disease (399.68 KB / PDF)

Nanotopographical features influence derivation and selection of reference genes for stem cell differentiation protocols (235.09 KB / PDF)

HepaRG progenitor cells commit to earlier hepatic differentiation and outperform metabolic function of control when cultured on nanopattern substrate (292.25 KB / PDF)

This article was published on 2024-08-22