Associations of peak-width skeletonized mean diffusivity and post-stroke cognition Link to paper on Life Authors Angela C. C. Jochems, Susana Muñoz Maniega, Una Clancy, Daniela Jaime Garcia, Carmen Arteaga, Will Hewins, Rachel Penman, Olivia K. L. Hamilton, Agnieszka Czechoń, Ellen V. Backhouse, Michael J. Thrippleton, Michael S. Stringer, Mark. E. Bastin, Maria del C. Valdés Hernández, Stewart Wiseman, Francesca M. Chappell, Fergus N. Doubal and Joanna M. Wardlaw Abstract Post-stroke cognitive impairment is common and can have major impact on life after stroke. Peak-width of Skeletonized Mean Diffusivity (PSMD) is a diffusion imaging marker of white matter microstructure and is also associated with cognition. Here, we examined associations between PSMD and post-stroke global cognition in an ongoing study of mild ischemic stroke patients. We studied cross-sectional associations between PSMD and cognition at both 3-months (N = 229) and 1-year (N = 173) post-stroke, adjusted for premorbid IQ, sex, age, stroke severity and disability, as well as the association between baseline PSMD and 1-year cognition. At baseline, (mean age = 65.9 years (SD = 11.1); 34% female), lower Montreal Cognitive Assessment (MoCA) scores were associated with older age, lower premorbid IQ and higher stroke severity, but not with PSMD (βstandardized = −0.116, 95% CI −0.241, 0.009; p = 0.069). At 1-year, premorbid IQ, older age, higher stroke severity and higher PSMD (βstandardized = −0.301, 95% CI −0.434, −0.168; p < 0.001) were associated with lower MoCA. Higher baseline PSMD was associated with lower 1-year MoCA (βstandardized = −0.182, 95% CI −0.308, −0.056; p = 0.005). PSMD becomes more associated with global cognition at 1-year post-stroke, possibly once acute effects have settled. Additionally, PSMD in the subacute phase after a mild stroke could help predict long-term cognitive impairment. Keywords Cognition Diffusion imaging Ischemic stroke Peak-width of skeletonized mean diffusivity Small vessel disease Citation Jochems ACC, Muñoz Maniega S, Clancy U, Jaime Garcia D, Arteaga C, Hewins W, Penman R, Hamilton OKL, Czechoń A, Backhouse EV, Thrippleton MJ, Stringer MS, Bastin ME, Valdés Hernández MdC, Wiseman S, Chappell FM, Doubal FN, Wardlaw JM. Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition. Life. 2022; 12(9):1362. https://doi.org/10.3390/life12091362 Related links Link to paper on Life Professor Joanna Wardlaw Angela Jochems Dr Susana Muñoz Maniega Dr Una Clancy Daniela Jaime Garcia Dr Michael Thrippleton Dr Michael Stringer Dr Mark Bastin Dr Maria Valdés Hernández Dr Stewart Wiseman Dr Francesca Chappell Dr Fergus Doubal Brain & nervous system Stroke Small vessel disease Social media tags and titles Featured paper: Associations of peak-width skeletonized mean diffusivity and post-stroke cognition @EdinUniBrainSci @AngelaJochems @fergusdoubal Publication date 06 Sep, 2022
