Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning & big data – A systematic review. Link to paper on Computerized Medical Imaging & Graphics Authors Ramya Balakrishnan, Maria del C.Valdés Hernández, Andrew J.Farrall Abstract Background: White matter hyperintensities (WMH), of presumed vascular origin, are visible & quantifiable neuroradiological markers of brain parenchymal change. These changes may range from damage secondary to inflammation & other neurological conditions, through to healthy ageing. Fully automatic WMH quantification methods are promising, but still, traditional semi-automatic methods seem to be preferred in clinical research. We systematically reviewed the literature for fully automatic methods developed in the last five years, to assess what are considered state-of-the-art techniques, as well as trends in the analysis of WMH of presumed vascular origin. Method: We registered the systematic review protocol with the International Prospective Register of Systematic Reviews (PROSPERO), registration number - CRD42019132200. We conducted the search for fully automatic methods developed from 2015 to July 2020 on Medline, Science direct, IEE Explore, & Web of Science. We assessed risk of bias & applicability of the studies using QUADAS 2. Results: The search yielded 2327 papers after removing 104 duplicates. After screening titles, abstracts & full text, 37 were selected for detailed analysis. Of these, 16 proposed a supervised segmentation method, 10 proposed an unsupervised segmentation method, & 11 proposed a deep learning segmentation method. Average DSC values ranged from 0.538 to 0.91, being the highest value obtained from an unsupervised segmentation method. Only four studies validated their method in longitudinal samples, & eight performed an additional validation using clinical parameters. Only 8/37 studies made available their methods in public repositories. Conclusions: We found no evidence that favours deep learning methods over the more established k-NN, linear regression & unsupervised methods in this task. Data & code availability, bias in study design & ground truth generation influence the wider validation & applicability of these methods in clinical research. Keywords Deep learning FLAIR hyperintensities Supervised segmentation Unsupervised segmentation White matter hyperintensities White matter lesions Related links Link to paper on Computerized Medical Imaging & Graphics Professor Andrew Farrall Dr Maria Valdes Hernandez Edinburgh Imaging Academy Brain & nervous system Social media tags & titles Featured paper: Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning & big data – A systematic review. #WMH @EdinUniNeuroImg @drajfarrall Publication date 03 Feb, 2021
