Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms Link to paper on EJNMMI Research Authors Samuel Debono, Jennifer Nash, Alexander J. Fletcher, Maaz B. J. Syed, Scott I. Semple, Edwin J. R. van Beek, Alison Fletcher, Sebastien Cadet, Michelle C. Williams, Damini Dey, Piotr J. Slomka, Rachael O. Forsythe, Marc R. Dweck & David E. Newby Abstract Background: Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to modify this method for use within the infrarenal aorta of patients with abdominal aortic aneurysms. Methods: Twenty-five patients with abdominal aortic aneurysms underwent an sodium [18F]fluoride positron emission tomography and computed tomography scan. Maximum and mean tissue-to-background ratios (TBR) and abdominal aortic microcalcification activity were determined following application of a thresholding and variable radius method to correct for vertebral sodium [18F]fluoride signal spill-over and the nonlinear changes in aortic diameter, respectively. Agreement between the methods, and repeatability of these approaches were assessed. Results: The aortic microcalcification activity method was much quicker to perform than the TBR method (14 versus 40 min, p < 0.001). There was moderate-to-good agreement between TBR and aortic microcalcification activity measurements for maximum (interclass correlation co-efficient, 0.67) and mean (interclass correlation co-efficient, 0.88) values. These correlations sequentially improved with the application of thresholding (intraclass correlation coefficient 0.93, 95% confidence interval 0.89–0.95) and variable diameter (intraclass correlation coefficient 0.97, 95% confidence interval 0.94–0.99) techniques. The optimised method had good intra-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.36 and limits of agreement − 0.43 to 0.43) and inter-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.47 and limits of agreement − 0.53 to 0.53) repeatability. Conclusions: Aortic microcalcification activity is a quick and simple method which demonstrates good intra-observer and inter-observer repeatabilities and provides measures of sodium [18F]fluoride uptake that are comparable to established methods. Keywords Aneurysms Image analysis Positron emission tomography Radiotracer Related links Link to paper on EJNMMI Research Professor David Newby Professor Marc Dweck Dr Michelle Williams Professor Edwin van Beek Professor Scott Semple Heart / cardiovascular Abdominal aortic aneurysm What is a PET scan? What is a CT scan? Social media tags and titles Featured paper: Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms @EdinUniCVS @MarcDweck @imagingmedsci Publication date 28 Jun, 2022