Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study Link to paper on Diagnosis, Assessment & Disease MonitoringAuthorsJamie Burke, Samuel Gibbon, Audrey Low, Charlene Hamid, Megan Reid-Schachter, Graciela Muniz-Terrera, Craig W. Ritchie, Baljean Dhillon, John T. O'Brien, Stuart King, Ian J. C. MacCormick, Thomas J. MacGillivray AbstractINTRODUCTIONWe explored associations between measurements of the ocular choroid microvasculature and Alzheimer's disease (AD) risk.METHODSWe measured the choroidal vasculature appearing in optical coherence tomography (OCT) scans of 69 healthy, mid-life individuals in the PREVENT Dementia cohort. The cohort was prospectively split into low-, medium-, and high-risk groups based on the presence of known risk factors (apolipoprotein E [APOE] ε4 genotype and family history of dementia [FH]). We used ordinal logistic regression to test for cross-sectional associations between choroidal measurements and AD risk.RESULTSChoroidal vasculature was progressively larger between ordinal risk groups, and significantly associated with risk group prediction. APOE ε4 carriers had thicker choroids and larger vascularity compared to non-carriers. Similar trends were observed for thoseKeywords:apolipoprotein E ε4choroidoptical coherence tomographyretinaRelated linksLink to paper on Diagnosis, Assessment & Disease MonitoringJamie BurkeSamuel GibbonGraciela Muniz-TerreraBaljean DhillonIan J. C. MacCormickThomas J. MacGillivray Social media tags and titlesFeatured Paper: Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study @EdinUniImaging @svdresearch.bsky.social This article was published on 2025-02-25
