Link to paper on Springer Nature
Authors
Lucia Ballerini, Ahmed E. Fetit, Stephan Wunderlich, Ruggiero Lovreglio, Sarah McGrory, Maria Valdes-Hernandez, Tom MacGillivray, Fergus Doubal, Ian J. Deary, Joanna Wardlaw, Emanuele Trucco
Abstract
The retinal & cerebral microvasculatures share many morphological & physiological properties.
In this pilot we study the strength of the associations between morphological measurements of the retinal vasculature, obtained from fundus camera images, & of features of Small Vessel Disease (SVD), as white matter hyperintensities (WMH) & perivascular spaces (PVS), obtained from MRI brain scans.
We performed a 500-trial bootstrap analysis with Regularized Gaussian linear regression on a cohort of older community-dwelling subjects (Lothian Birth Cohort 1936, N = 866) in their eighth decade.
Arteriolar bifurcation coefficients, vessel tortuosity & fractal dimension predicted WMH volume in 23% of the trials.
Arteriolar widths, venular bifurcation coefficients, & venular tortuosity predicted PVS in up to 99.6% of the trials.
Keywords
- Biomarkers
- Retina
- Small vessel disease
Social media tags & titles
Featured paper: Retinal biomarkers discovery for cerebral small vessel disease in an older population. @lucia_ballerini @EdinUniLBC #SmallVesselDisease #Retina