Small vessel disease (SVD) of the brain relates to abnormalities of the tiny vessels known as arterioles, capillaries & venules & encompasses a range of neuroimaging, pathological, & associated clinical features. Overview Our research aims to determine the pathophysiology of cerebral small vessel disease including lacunar stroke, using medical imaging, particularly magnetic resonance, laboratory methods & clinical research methods in cohort studies & clinical trials.We have pioneered developments in blood-brain barrier permeability & cerebrovascular reactivity imaging, as well as advanced image analysis methods for SVD, & integration of multi-modality DTI, spectroscopy, structural & blood flow imaging.Current projects include cross sectional & longitudinal analysis of patients with stroke or cognitive presentations of SVD, to understand more about how & why SVD lesions develop & to develop treatments. These include the mild stroke study I, II & now III, the Foundation Leduq study of Sleep Apnoea, the UK Dementia Research Institute, SVD study (MSS3), the EU H2020 funded SVDs@Target studies of blood brain barriers & CVR (Investigate@SVD’s) & anti-hypertensive treatment (treat@SVD) & EPSRC funded studies of the retina & brain to detect early signs of SVD, & many studies of image analysis methods including developing approaches including industry collaborations funded by Innovative.We recently completed the AI2 Soc funded Lacunar Intervention Trial – 1 (LACI-1) & are now running the BHF funded LACI-2, which aims to prevent worsening SVD.The RowFogo centre for research into Aging & the brain recognises this body of work & forms a hub for future SVD research in Edinburgh. Lead SVD researcher Prof Joanna Wardlaw To discuss new research & collaborative imaging projects with Edinburgh Imaging, please contact: Edinburgh Imaging Enquiries: studies / collaborations / facilities Contact details Email: edimg.studyinfo@ed.ac.uk Research staff with a SVD focus Listed alphabetically:Prof Andrew FarrallDavid RodriguezMs Eleni SakkaDr Fergus DoubalDr Francesca ChappellProf Ian MarshallMs Iona HamiltonDr Lizzie HillDr Lucia Ballerini Dr Maria Valdés HernándezDr Mark BastinDr Michael StringerDr Michael ThrippletonDr Rosalind BrownDr Stewart WisemanDr Susana Munoz ManiegaDr Tom MacGillivray Current projectsCompleted projects Funding organisations & research groups Listed alphabetically:Alzheimer's SocietyBritish Heart FoundationChest Heart & Stroke ScotlandChief Scientist OfficeEngineering and Physical Sciences Research CouncilEU Horizon 2020 ProgrammeFondation LeducqInnovate UKPerivascular spaces in SVDRow Fogo Charitable TrustStroke AssociationWellcome Trust Relevant links 30 Sep 23. Lucia MacCioni CZI-PiW scholar06 Apr 22. Dr Jose Bernal Moyano gains PhD24 Feb 22. Dr Una Clancy gains PhD15 Jul 21. Dr Olivia Hamilton gains PhD04 Dec 20. LACI-2 study resumed11 Nov 20. Harvey Prize Symposium08 Oct 20. INVESTIGATE@SVDs study ends14 Sep 20. RSM virtual meeting27 Mar 20. INVESTIGATE@SVDs Milestone16 Jan 20. TREAT-SVDs Milestone23 Apr 19. Investigate@SVDs final volunteer16 Aug 18. Age UK article05 Jul 18. Drug hope for dementia & stroke05 Jul 17. Investigate@SVDs starts Relevant Edinburgh Imaging publications 02 Sep 22. Featured Paper. Associations of peak-width skeletonized mean diffusivity and post-stroke cognition26 Aug 22. Featured Paper. Topological relationships between perivascular spaces and progression of white matter hyperintensities: A pilot study in a sample of the Lothian Birth Cohort 193616 Aug 22. Featured Paper. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI05 Aug 22. Featured Paper. Assessment of perivascular space filtering methods using a three-dimensional computational model05 Jul 22. Featured Paper. A link between frontal white matter integrity and dizziness in cerebral small vessel disease27 Jun 22. Featured Paper. Systematic review of cerebral phenotypes associated with monogenic cerebral small‐vessel disease07 Jun 22. Featured Paper. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model03 Jun 22. Featured Paper. Prevalence and significance of the vessel-cluster sign on susceptibility-weighted imaging in patients with severe small vessel disease22 Nov 21. Featured Paper. Tracer kinetic assessment of blood–brain barrier leakage & blood volume in cerebral small vessel disease: Associations with disease burden & vascular risk factorsPlease view all our publications, here This article was published on 2024-08-22