Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases Link to article on Stroke Authors Joanna M. Wardlaw and David S. Liebeskind Abstract Stroke research has largely focused on blood supply to the brain, particularly via large arteries leading from the heart, the muscular intracranial large arteries, large cerebral veins and venous sinuses, and more recently perforating arterioles, capillaries, and venules. However, these blood vessels only serve part of the brain’s fluid management, nutrient delivery, and waste clearance system. The other, and until recently largely neglected, aspect of brain fluid and waste management is the system that flushes the brain, draining interstitial and cerebrospinal fluid (CSF) and waste from the cranial cavity. Details of this non–blood-vessel brain circulation are incomplete, but there is now enough clinical relevance for it to be the focus of this Advances in Stroke: Diagnosis and Imaging, particularly as key elements are now visible on routine magnetic resonance imaging (MRI). Keywords Brain Cerebrospinal fluid Cerebrovascular disorders Edema Extra cellular fluid Hydrocephalus Meninges Related links Link to article on Stroke Professor Joanna Wardlaw Brain & nervous system Stroke What is a MR scan? Social media tags and titles Featured article: Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases @EdinUniBrainSci Publication date 27 Apr, 2022