22 Feb 22. PhD - Neurodegeneration in MS

DEADLINE: 28 Feb 22

DIRECT APPLICATIONS TO: Find out more

PROJECT TITLE: "Measuring neurodegeneration in models of multiple sclerosis using positron emission tomography (PET)"

CENTRE: Centre for Clinical Brain Sciences

SUPERVISOR: Professor Adam Waldman

FURTHER INFORMATION

The project will involve testing a new synaptic vesicle glycoprotein (SV2A) PET ligand called [18F]MNI11263 for measuring synaptic density on brain tissue sections in whole mouse brain with global (cuprizone) and focal1 cortical demyelination, and finally in vivo in the same mouse models.

Neurodegeneration will be compared with and without repair/neuroprotection strategies, to understand the opportunities for detecting neuronal damage and the effects of targeted treatments in MS.

Training opportunities include PET ligand chemistry, pre-clinical neuroimaging tissue immunofluorescence/microscopy/image analysis/pathology, in vivo mouse disease modelling, PET methodology and analysis, as well as engagement with people with MS and outreach through the MS Centre.

Please find further information on the PhD studentship, here.